Chromatin dynamics: nucleosomes go mobile through twist defects.
نویسندگان
چکیده
We study the spontaneous "sliding" of histone spools (nucleosomes) along DNA as a result of thermally activated single base pair twist defects. To this end we map the system onto a suitably extended Frenkel-Kontorova model. Combining results from several recent experiments we are able to estimate the nucleosome mobility without adjustable parameters. Our model shows also how the local mobility is intimately linked to the underlying base pair sequence.
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ورودعنوان ژورنال:
- Physical review letters
دوره 91 14 شماره
صفحات -
تاریخ انتشار 2003